Neural Mechanisms of Inhibitory Response in a Battlefield Scenario: A Simultaneous fMRI-EEG Study

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• Frontiers in Human Neuroscience (Open Access)

Abstract

Understanding the neural basis of inhibitory control under realistic conditions is critical for translational neuroscience. This study employed a battlefield-themed go/no-go paradigm — replacing abstract symbols with combat-relevant stimuli — during simultaneous fMRI-EEG recording. Behavioral results confirmed robust inhibition with high ecological engagement. fMRI revealed activation of the right inferior frontal gyrus, pre-supplementary motor area, and anterior cingulate cortex during successful response inhibition. EEG-derived event-related potentials (ERPs) showed enhanced N2 and P3 components over frontocentral electrodes during no-go trials, consistent with inhibitory monitoring and control. Joint analysis of fMRI and EEG signals indicated that the timing and localization of inhibitory processes are sensitive to motivational context, underscoring the role of affective engagement in shaping executive control.

Citation

Ko, L.-W., Shih, Y.-C., Chikara, R. K., Chuang, Y.-T., & Chang, E. C. (2016). Neural mechanisms of inhibitory response in a battlefield scenario: A simultaneous fMRI-EEG study. Frontiers in Human Neuroscience, 10, 185.

@article{Ko2016,
  author  = {Ko, Li-Wei and Shih, Yi-Cheng and Chikara, Rupesh Kumar and Chuang, Ya-Ting and Chang, Erik C.},
  year    = {2016},
  title   = {Neural Mechanisms of Inhibitory Response in a Battlefield Scenario: A Simultaneous fMRI-EEG Study},
  journal = {Frontiers in Human Neuroscience},
  volume  = {10},
  pages   = {185},
  doi     = {10.3389/fnhum.2016.00185}
}